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Murukeshan Vadakke Matham


Murukeshan Vadakke Matham
Associate Professor
Tel: 6790 4200
Email: mmurukeshan@ntu.edu.sg
Office: N3.2-02-75 
   
Education
  • PhD Indian Institute of Technology, Madras 1997
  • MPhil Cochin Univ of Science & Technology 1991
  • MSc Cochin Univ of Science & Technology 1988
  • BSc University of Calicut, Kerala 1986

Biography
Dr. Murukeshan Vadakke Matham graduated from the University of Calicut, India with Physics as his major. He obtained his MSc and MPhil degrees in Physics with specialization in Quantum Electronics from the Cochin University of Science and Technology (CUSAT), India. He pursued his doctoral degree in Applied Optics at the Indian Institute of Technology, Madras and at the University of Oldenburg, Germany under the DAAD Fellowship award and was awarded Ph.D. in 1997. Since 1997 he is with the School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore where he is currently working as an Associate Professor of optical engineering. He has extensive teaching and research experience of over two decades, in the area of optical engineering and his major research interests are Nanoscale Optics, Biomedical Optics and Optical metrology. He has delivered over 50 keynote/plenary/invited talks at international workshops, conferences or forums. He has authored or co-authored of over 250 international research articles, which include 140 international journal papers, more than 110 international conference proceedings papers/presentations and 6 book chapters. Prof. Murukeshan also holds 6 patents and 8 innovation disclosures. He serves in the editorial boards of international journals such as the joint editor of Journal of Holography and Speckle (JHS) and Associate editor of Journal of Medical Imaging and Health Informatics (JMIHI) and International Journal of Optomechatronics (IJO). He is also a regular reviewer for more than 10 leading high impact factor optics journals.

He leads a research group which focuses on cutting edge research on Nanoscale optics, Biomedical optics and Applied optics for metrology. His research has fetched more than S$8 million through competitive and industry funding in the recent years. For his contributions, Prof. Murukeshan has won many international recognitions and awards such as DAAD Fellowship (Germany), TCT Fellowship, PMO- Technical Challenge Award (Singapore), Member, Award committee, SPIE (USA) to name a few. He was Visiting researcher (Japan), Visiting Associate Professor- Uni. California(US), Erudite Professor, University of Kerala ( India). He is also nominated for two prestigious international fellowships. He has supervised/ co-supervised ( includes on-going) the research theses of over 21 PhD students and 4 MEngg (students. Many of his student research papers have won awards at international conferences. He is currently the Deputy Director of Centre for Optical and Laser Engineering (COLE), NTU, and holds a concurrent adjunct appointment as Principal Research Scientist at the famous Singapore Eye Research Institute (SERI). He is a Fellow of the Institute of Physics, UK.

Research
  • Interest:
    Nanoscale Optics-  Near field optics ( evanescent wave and Plasmonics), and Random media; Biomedical Optics ( Imaging and Sensing)- High resolution probe imaging, Multi modality ( optical and hybrid optical) imaging, Photoacostics, hyperspectral imaging and Applied Optics for Micro and nano-scale metrology, NDT&E Ocular imaging, Breast Cancer diagnosis
  • Projects:
    Nanoscale Optics
    This project focuses on developing new generation non contact high aspect ratio nanoscale features that can find potential applications in semiconductor industry, improving thin film Si solar cell efficiency and for biomedical optics. Both conventional and near filed optics such as evanescent waves and plasmonics are heavily researched over the last few years. Current research focuses on achieving the forecasted technology nodes of sub 10nm as well as generating of new devices using such structures.
    [COLE, Micro-Systems & Optics]
    Multi- modality Biomedical Optics and Imaging
    This project aims at developing new generation multi optical and hybrid optical imaging methodologies as well as molecular probes for early disease diagnosis  focusing on colon, breast and ocular). High resolution (axial, temporal and spatial) and clinician and patient friendly design adoption are targeted in this research while developing the technology. Two patents are already filed and many technology disclosures are in the pipeline in this challenging area.   Multi and Hyperspectral Imaging, High resolution specialty fiber optic probes, Photoacoustic Imaging, Special beam profile assisted imaging will be  integrated in a single setting to derive the benefits of different imaging modalities.
    [COLE/LKC Medical School/SERI, Micro-Systems & Optics]
    Improved Broad band absorption thin film solar cells
    Tapping natural resources for energy has become the current focus of research all over the world and harnessing of solar energy tops the priority list. In this context, photovoltaics is emerging as a promising technology for converting solar energy into electricity in usable as well as storable forms, renewing the hopes of mankind to solve the energy crisis looming large particularly over the technological progress of the coming generations. Conventional solar cell is not feasible economically at present, in view of the high costs of silicon materials and processing. Therefore thin film solar cells are of great interest in solar cell market because of the small film thickness. But the absorbance of light in the near bandgap region is small and hence structuring of layers and proper configuration of the layered structure of thin film solar cell are very crucial. This project in this context focuses on the specific objectives of achieving improved light absorption and conversion efficiency in thin film solar cells using the proposed strategies. Plasmonics, gap modes concepts will be employed with novel configurations for achieving the targeted conversion efficiency.
    [COLE, Micro-Systems & Optics]
    Near field Optics Controlled random media- Fundamental Investigation with Potential applications
    Nearfield optical concepts are introducing a paradigm shift in a wide variety of science and engineering fields and the most significant applications of this fundamental physics-optics concepts have been towards meeting the applied engineering problems of today. Furthermore, non contact optical methodologies for writing patterned structures or features have enabled such near field assisted device fabrication and related applications. Optics technology that focuses on the above mentioned areas has seen the impact of the same with a challenging trend to achieve smaller features at the nanoscale. Integrated near filed concepts exploiting such features and nanoscale metal particles in a random disordered media is one of the latest thrust research area, which is expected to make potential impacts in a wide variety of fields. The major research contents of this project in this context aim at the fundamental research and investigation into such Near field Optics Controlled random media- Both Fundamental Investigation and potential device fabrication will be explored.
    [COLE, Micro-Systems & Optics]
    Feasibility study on image fiber integration into a hyper-spectral imaging unit with a sophisticated mechanical and conceptual design
    Multi- or Hyper-spectral imaging is the acquisition of spectra information, together with spatial information. 2D spatial information is generally done via scanning of the sample. However, it was always challenging to integrate speciality optical fibers such as image fibers to integrate into such system for simultaneous imaging and fluorescence sensing which can find specific applications in different targeted fields. This project entitled “Feasibility study on image fiber integration into a hyper-spectral imaging unit with a sophisticated mechanical and conceptual design” has the following main objective:
    To investigate and conduct a feasibility study on the physical constraint, to improvise, devise and design a flexible system to couple image fiber into a hyper-spectral imaging unit.
    [COLE, Micro-Systems & Optics]
    Investigations into Digital Analysis of Hyperspectral Data
    Hyper-spectral imaging is the acquisition of spectra information, together with spatial information. 2D spatial information is generally done via scanning of the sample. However, a sophisticated software with targeted objectives is a challenge. Hence this project aims at coming up with a digital analysis and classification approach to extract useful information from raw hyper-spectral data. The investigation will primarily be on feasibility and subsequent integration with the hardware.
    [COLE, Micro-Systems & Optics]
    Surface Finish Measurement of Difficult to Access areas and Internal Channels
    Traditional surface finish measurement systems are either stylus based or benchtop optical systems. Both are unable to effectively measurement difficult to access areas because of the geometry of the part, or internal channels. Therefore, there is a need to develop a capable measurement system to address this gap. The aim of this project in this context is to research and develop non- contact probe metrology solutions for Surface Finish Measurement of Difficult to Access areas and Internal Channels.
    [COLE/NTU @ RR Corp Lab, Micro-Systems & Optics]
    Next generation large area dimensional measurement
    This project would focus on non-contact optical in-situ measurement techniques to detect feature presence/intensity of feature presence and will serve as an important feed-back loop to adapt the advanced mechanized finishing process. The research will mainly focuses on the diagnostic monitoring that can detect features on the surface, measure sharp edges and represent the surface in 2 D and 3D highlighting the detected features.
    [COLE/NTU @ RR Corp Lab, Micro-Systems & Optics]
    Ocular imaging of irido-corneal angle with overlay of fluorescent emission distribution
    Glaucoma is the leading cause of irreversible blindness worldwide, with primary angle closure glaucoma (PACG) a major form of glaucoma in Singapore and Asia. High resolution anterior segment imaging of the human eye for the diagnosis and management of various eye diseases (including corneal diseases and glaucoma) is an area of unmet need. This is due to limitations with the current available technologies related to the diagnosis and quantification of angle closure.
    In this project, we aim to develop a novel anterior segment diagnostic device using self-constructing beam imaging coupled with fluorescence imaging, that can image the drainage pathway (trabecular meshwork) of the eye directly and provide 3D images with better resolution (<10 m) than currently available, as well as explore dynamic features of aqueous humor flow.
    [COLE/SERI, Micro-Systems & Optics]

Research Staff and Students under supervision

Research Staff
Name Title Email
Patinharekandy Prabhathan Research Fellow PPRABHATHAN@ntu.edu.sg
Sandeep Menon Perinchery Research Fellow SANDEEPMP@ntu.edu.sg
Jayachandra Bingi Research Associate JBINGI@ntu.edu.sg
Hong Xun Jie Jesmond Project Officer JESMONDHONG@ntu.edu.sg
Lim Hoong Ta Project Officer LIMHT@ntu.edu.sg

PhD Students
Name Project
Hong Xun Jie Jesmond Investigations into High Resolution Imaging of Open and Close Angles in Glaucoma Patients
Xia Yang Investigation multimodal molecular probes and effect of Nanoparticles in Diagnostic Bio-imaging
Lim Hoong Ta Diagnostic High Resolution Hyperspectral Multi-modality Optical Imaging Probes for Biomedical Applications
Anant Shinde Investigations into Specialty Fiber Optics Based Imaging Probe with Improved Signal Processing and Resolution for Diagnostic Medical Applications
Valiyambath Krishnan Mohankumar Investigations into High Resolution Imaging and Contouring for Diagnostic Bio-Applications
Ratheesh Kumar Meleppat Investigation into Frequency Domain OCT Imaging and Its Diagnostic Applications

Selected Publications

Nanoscale Optics:
  • Jeun Kee Chua, Vadakke Matham Murukeshan, Sia Kim Tan, Qun Ying Lin , Four beams evanescent waves interference lithography for patterning of two dimensional features, Optics Express, 15(6) , 3437-3451 (2007).
  • V. M. Murukeshan*, J. K. Chua, S. K. Tan, and Q. Y. Lin, "Nano-scale three dimensional surface relief features using single exposure counterpropagating multiple evanescent waves interference phenomenon," Opt. Express 16, 13857-13870 (2008).
  • K. V. Sreekanth, V. M. Murukeshan* and J. K. Chau, “A planar layer configuration for surface plasmon interference nanoscale lithography”, Applied Physics Letters 93, (9), 093103 (2008).
  • V.M.Murukeshan*, K. V. Sreekanth, “Excitation of gap modes in a metal particle-surface system for sub-30 nm plasmonic lithography” Optics Letters 34 (6), 845-847 (2009).
  • K. V. Sreekanth, J. K. Chua and V. M. Murukeshan*, “Interferometric lithography for nano-scale feature patterning: A comparative analysis between laser interference, evanescent wave interference and surface plasmon interference”, Applied Optics 49, 6710 (2010) .
  • Sathiyamoorthy, K., Sreekanth, K.V., Sidharthan, R., Murukeshan, V.M*., Xing, B., Surface plasmon enhancement in gold nanoparticles in the presence of an optical gain medium: An analysis , Journal of Physics D: Applied Physics 44 (42), art. no. 425102, 2011.
  • K. V. Sreekanth and V. M. Murukeshan*, “Multiple beams surface plasmon interference generation: A theoretical analysis”, Optics Communications, 284, 2042 (2011).
  • Periodic feature patterning by lens based solid immersion multiple beam laser interference lithography, R. Sidharthan, and V. M. Murukeshan*, Laser Physics Letters, 2012, 9, 691.
  • Sidharthan, R.; Murukeshan, V. M*, "Improved light absorption in thin film solar cell using combination of gap modes and grating back reflector ", THIN SOLID FILMS Volume: 548   Pages: 581-584, 2013.
  • Sidharthan Raghuraman, Manish Kumar; Joby Joseph, Murukeshan V Matham*, Realization of body centered tetragonal, beta-tin and diamond type structures using five beam interference, Optics Communications, Volume 322,  Pages 160-163 (2014)

Biomedical Optics:
  • Shinde, A., & Matham, M. V. Pixelate Removal in an Image Fiber Probe Endoscope  incorporating Comb Structure Removal Methods. Journal of Medical Imaging and Health Informatics, 4(2), 203-211, 2014. DOI: 10.1166/jmihi.2014.1255 
  • Prabhathan, P.K., Murukeshan, V. M. Silicon Waveguide Multiplexed Sensor Array Configuration for Label-Free Biosensing Applications. Journal of the Indian Institute of Science, 94(3). 2014.
  • Shinoj, V. K., Murukeshan, V. M., Tor, S. B., Loh, N. H., & Lye, S. W. Design, fabrication, and characterization of thermoplastic microlenses for fiber-optic probe imaging. Applied optics, 53(6), 1083-1088, 2014 DOI: 10.1364/AO.53.001083 
  • James, J., Murukeshan, V. M., & Woh, L. S. Integrated photoacoustic, ultrasound and fluorescence platform for diagnostic medical imaging-proof of concept study with a tissue mimicking phantom. Biomedical optics express,5(7),2135-2144, 2014. DOI: 10.1364/BOE.5.002135
  • Shinoj, V. K., Murukeshan, V. M., Baskaran, M., & Aung, T. Note: A gel based imaging technique of the iridocorneal angle for evaluation of angle-closure glaucoma. Review of Scientific Instruments 85, 066105, 2014. DOI: 10.1063/1.4882335
  • Sathiyamoorthy, K., Ramya, B., Murukeshan, V.M. & Sun, X.W. Modified two prism SPR sensor configurations to improve the sensitivity of measurement. Source of the Document Sensors and Actuators, A: Physical, 191,73-77. DOI: 10.1016/j.sna.2012.11.029 ,
  • Krishnan, M. V., Matham, M. V., Krishnan, S., Parasuraman, P., Joseph, J., & Bhakoo, K. Red, green, and blue gray-value shift-based approach to whole-field imaging for tissue diagnostics. Journal of biomedical optics, 17, no.7,0760101-0760106. DOI: 10.1117/1.JBO.17.7.076010.
  • Shinoj, Vengalathunadakal Kuttinarayanan, and Vadakke Matham Murukeshan. Hollow-core photonic crystal fiber based multifunctional optical system for trapping, position sensing, and detection of fluorescent particles. Optics letters 37, no. 10, 1607-1609. DOI: 10.1364/OL.37.001607.
  • Shinoj, V.K. & Murukeshan, V.M. An integrated hollow-core photonic crystal fiber transverse optical trapping system for optical manipulation and detection. Journal of Applied Physics 111, 023106-023106-023105 DOI: 10.1063/1.3676248.
  • Joseph, J., Sathiyamoorthy, K., Murukeshan, V.M. & Woh, L.S. Thermal diffusivity variations in nanoparticle administered phantom tissues - a photoacoustic investigation. The European Physical Journal - Applied Physics 59 DOI: 10.1051/epjap/2012120060.
  • Saraswathi P, V K Shinoj, V M Murukeshan, and P Padmanabhan, Highly sensitive optical detection of specific protein in breast cancer cells using Micro structured fiber in extremely low sample volume, Journal of Biomedical Optics 15(1)(2010). DOI: 10.1117/1.3302810 
  • L.K. Seah, P. Wang, V.M. Murukeshan, Z.X. Chao, “Application of fluorescent life time imaging (FLIM) in latent fingermark detection”, Forensic science International, 160 (2-3), 109-114, 2006. DOI: 10.1016/j.forsciint.2005.08.018

Teaching
  • Fundamentals Of Precision Engineering
  • Optical Engineering
  • Optical Metrology & Instrumentation
  • Laser Assisted Manufacturing