Design and development of a compact swept source optical coherence tomography (SSOCT) imaging system with enhanced imaging capability for bio imaging applications.

Principal Investigator: Associate Professor Seah Leong Keey

Email:

mlkseah@ntu.edu.sg

Office:

N3-02b-47

Tel:

(65) 6790 4824

Last Update: Jan 2017

PROJECT DESCRIPTION:

The project aim to develop a novel fiber optic interferometer and galvo mirror based beam delivery system. The system is capable of real-time data acquisition using high speed digitizer and control signal generation for laser beam steering setup for imaging. The SSOCT system uses an efficient wavenumber calibration scheme. The developed system can be applied to 1) In situ and quantitative imaging of bacterial biofilm using OCT/OCM, 2) Nanoparticle based contrast enhancement and photothermal applications, and 3) Anterior chamber imaging for Glaucoma detection.

PUBLICATIONS:

  1. K M Ratheesh, L. K. Seah and V M Murukeshan. ”Spectral phase-based automatic calibration scheme for swept source based optical coherence tomography systems”. Physics in Medicine and Biology, Vol 61, No. 2, Oct 2016.
  2. K M Ratheesh, P Prabhathan, L K Seah and V M Murukeshan. “Gold nanorods with higher aspect ratio as potential contrast agent in optical coherence tomography and for photothermal applications around 1300 nm imaging window”. Biomedical Physics & Engineering Express, Vol. 2, N0. 5, Sept 2016.
  3. R K Meleppat, P Prabhathan, Seah L.K., and M V Matham. “Plasmon Resonant Silica Coated Silver Nanoplates as Contrast Agents for Optical Coherence Tomography”. Journal of Biomedical Nanotechnology, Vol 12, 1929–1937 (2016).